Platelet Rich Plasma
Platelet-rich plasma (PRP) is a by-product of blood (plasma) that is rich in platelets. Until now, its use has been confined to the hospital setting.
This was due mainly to the cost of separating the platelets from the blood and a large amount of blood needed to produce a suitable quantity of platelets. New technology permits doctors to harvest and produce a sufficient quantity of platelets from only 55 ccs of blood, which is drawn from the patient while they are having outpatient surgery.
- Why All The Excitement About PRP?
- PRP Has Many Clinical Applications
- PRP Also Has Many Advantages
- Frequently Asked Questions About PRP
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Why All The Excitement About PRP?
PRP permits the body to take advantage of the normal healing pathways at a greatly accelerated rate. During the healing process, the body rushes many cells and cell types to the wound in order to initiate the healing process.
One of those cell types is platelets. Platelets perform many functions, including the formation of a blood clot and the release of growth factors (GF) into the wound.
These growth factors; platelet-derived growth factors (PDGF), transforming growth factor-beta (TGF), and insulin-like growth factor (ILGF), function to assist the body in repairing itself by stimulating stem cells to regenerate new tissue. The more growth factors released and sequestered into the wound, the more stem cells are stimulated to produce new tissue.
Thus, PRP permits the body to heal faster and more efficiently.
A subfamily of TGF is a bone morphogenic protein (BMP). BMP has been shown to induce the formation of new bones in research studies on both animals and humans. This is of great significance to the surgeon who places dental implants.
By adding PRP, and BMP, to the implant site with bone substitute particles, the implant surgeon can now grow bone more predictably and faster than ever before.
PRP Has Many Clinical Applications
PRP can be used to aid Bone grafting for dental implants. This includes onlay and inlay grafts, sinus lift procedures, ridge augmentation procedures, closure of cleft and/or lip, and palate defects.
It can also assist in the repair of bone defects created by the removal of teeth, or small cysts and the repair of fistulas between the sinus cavity and mouth.
PRP Also Has Many Advantages
PRP is a by-product of the patient’s own blood, therefore, disease transmission is not an issue.
PRP can be generated in the doctor’s office while the patient is undergoing an outpatient surgical procedure such as the placement of dental implants.
The supersaturation of the wound with PRP, and thus growth factors, produces an increase in tissue synthesis and faster tissue regeneration.
Since PRP harvesting is done with only 55 ccs of blood in the doctor’s office, the patient need not incur the expense of the harvesting procedure in a hospital or at a blood bank.
Ease of use
PRP is easy to handle and actually improves the ease of application of bone substitute materials and bone grafting products by making them more gel-like.
Frequently Asked Questions About PRP
Is PRP safe?
Yes. During the outpatient surgical procedure, a small amount of your own blood is drawn out via the IV. This blood is then placed in the PRP centrifuge machine and spun down. In less than 15 minutes, the PRP is formed and ready to use.
Should PRP be used in all bone-grafting cases?
Not always. In some cases, there is no need for PRP. However, in the majority of cases, the application of PRP to the graft will increase the final amount of bone present, in addition to making the wound heal faster and more efficiently.
Will my insurance cover the costs?
Unfortunately not. The cost of the PRP application (approximately $400) is paid by the patient.
Can PRP be used alone to stimulate bone formation?
No. PRP must be mixed with either the patient’s own bone, a bone substitute material such as demineralized freeze-dried bone, or a synthetic bone product, such as BIO-OSS.
Are there any contraindications to PRP?
Very few. Obviously, patients with bleeding disorders or hematologic diseases do not qualify for this in-office procedure. Check with your surgeon and/or primary care physician to determine if PRP is right for you.
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